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Therapy Name FS222
Synonyms
Therapy Description

FS222 is a tetravalent bispecific antibody that binds to PD-L1 (CD274) and CD137 (4-1BB), which crosslinks cytotoxic T-lymphocytes to PD-L1-expressing tumor cells, potentially resulting in CD137 mediated activation of T-cells (PMID: 32345647).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
FS222 FS-222|FS 222 Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 133 TNFRSF9 Antibody 36 FS222 is a tetravalent bispecific antibody that binds to PD-L1 (CD274) and CD137 (4-1BB), which crosslinks cytotoxic T-lymphocytes to PD-L1-expressing tumor cells, potentially resulting in CD137 mediated activation of T-cells (PMID: 32345647).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04740424 Phase I FS222 FS222 First in Human Study in Patients With Advanced Malignancies Recruiting ROU | POL | NLD | ESP | DEU | AUS 1


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