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Therapy Name BNT111
Synonyms
Therapy Description

BNT111 is a liposomal RNA vaccine comprising mRNA transcripts that encode wild-type NY-ESO1, MAGE-A3, TYR (aa 1-477), and TPTE tumor specific antigens (TSAs), which is targeted to and expressed in dendritic cells, potentially inducing cytotoxic T-cell response against NY-ESO1, MAGE-A3, TYR, and TPTE expressing tumor cells (PMID: 32728218).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BNT111 BNT-111|BNT 111 BNT111 is a liposomal RNA vaccine comprising mRNA transcripts that encode wild-type NY-ESO1, MAGE-A3, TYR (aa 1-477), and TPTE tumor specific antigens (TSAs), which is targeted to and expressed in dendritic cells, potentially inducing cytotoxic T-cell response against NY-ESO1, MAGE-A3, TYR, and TPTE expressing tumor cells (PMID: 32728218).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04526899 Phase II Cemiplimab BNT111 BNT111 + Cemiplimab A Study to Investigate the Novel Agent BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Advanced Melanoma That Has Not Responded to Other Forms of Treatment Active, not recruiting USA | POL | ITA | GBR | ESP | DEU | AUS 0


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