Therapy Detail
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| Therapy Name | BNT111 |
| Synonyms | |
| Therapy Description |
BNT111 is a liposomal RNA vaccine comprising mRNA transcripts that encode wild-type NY-ESO1, MAGE-A3, TYR (aa 1-477), and TPTE tumor specific antigens (TSAs), which is targeted to and expressed in dendritic cells, potentially inducing cytotoxic T-cell response against NY-ESO1, MAGE-A3, TYR, and TPTE expressing tumor cells (PMID: 32728218). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BNT111 | BNT-111|BNT 111 | BNT111 is a liposomal RNA vaccine comprising mRNA transcripts that encode wild-type NY-ESO1, MAGE-A3, TYR (aa 1-477), and TPTE tumor specific antigens (TSAs), which is targeted to and expressed in dendritic cells, potentially inducing cytotoxic T-cell response against NY-ESO1, MAGE-A3, TYR, and TPTE expressing tumor cells (PMID: 32728218). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04526899 | Phase II | Cemiplimab BNT111 BNT111 + Cemiplimab | A Study to Investigate the Novel Agent BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Advanced Melanoma That Has Not Responded to Other Forms of Treatment | Active, not recruiting | USA | POL | ITA | GBR | ESP | DEU | AUS | 0 |
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