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Therapy Name | BT8009 |
Synonyms | |
Therapy Description |
BT8009 consists of a Nectin-4 binding bicyclic peptide linked to the toxin MMAE, which delivers the toxin to Nectin-4-expressing tumor cells, potentially resulting in tumor growth inhibition (PMID: 36112771). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
BT8009 | BT-8009|BT 8009 | BT8009 consists of a Nectin-4 binding bicyclic peptide linked to the toxin MMAE, which delivers the toxin to Nectin-4-expressing tumor cells, potentially resulting in tumor growth inhibition (PMID: 36112771). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT04561362 | Phase Ib/II | BT8009 BT8009 + Pembrolizumab | Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies | Recruiting | USA | ITA | GBR | FRA | ESP | CAN | 0 |
NCT06225596 | Phase II | Avelumab + Carboplatin + Gemcitabine Avelumab + Cisplatin + Gemcitabine BT8009 BT8009 + Pembrolizumab | Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2) | Recruiting | USA | TUR | POL | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS | ARG | 5 |