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Therapy Name EMB-02
Synonyms
Therapy Description

EMB-02 is a bispecific antibody that targets both PD-1 (CD279) and lymphocyte activation gene 3 protein (LAG-3), which degrades PD-1- and LAG-3 to induce T cell effector function, potentially leading to a cytotoxic T lymphocyte response against tumor cells (NCI Drug Dictionary, Ann Oncol 34 (2023): S625).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
EMB-02 EMB 02|EMB02 Immune Checkpoint Inhibitor 149 LAG3 Antibody 18 PD-L1/PD-1 antibody 121 EMB-02 is a bispecific antibody that targets both PD-1 (CD279) and lymphocyte activation gene 3 protein (LAG-3), which degrades PD-1- and LAG-3 to induce T cell effector function, potentially leading to a cytotoxic T lymphocyte response against tumor cells (NCI Drug Dictionary, Ann Oncol 34 (2023): S625).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04618393 Phase Ib/II EMB-02 A Study of EMB-02 in Participants With Advanced Solid Tumors Terminated USA | AUS 1


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