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Therapy Name Cemiplimab + REGN6569
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cemiplimab Libtayo REGN2810|SAR439684 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 Libtayo (cemiplimab) is a human antibody that targets PD-1 (PDCD1) and prevents interaction with PD-L1 (CD274) and PD-L2 (PDCD1LG2), potentially resulting in increased anti-tumor immune response and decreased tumor growth (PMID: 28265006). Libtayo (cemiplimab) is FDA approved for use in patients with cutaneous squamous cell carcinoma, who are not not eligible for curative surgery or radiation, in patients with locally advanced or metastatic basal cell carcinoma who have received or are not eligible for a hedgehog pathway inhibitor, as first-line treatment in patients with advanced non-small cell lung cancer (NSCLC) with high PD-L1 expression (TPS>=50%) and no EGFR, ALK, or ROS1 aberrations, and in combination with platinum-based chemotherapy as first-line treatment for patients with NSCLC without EGFR, ALK, or ROS1 alterations (FDA.gov).
REGN6569 REGN-6569|REGN 6569 GITR Antibody 7 REGN6569 is a monoclonal antibody that binds to and activates the glucocorticoid-induced tumor necrosis factor receptor (GITR, TNFRSF18) expressed on immune cells, potentially leading to activation and proliferation of effector T cells and anti-tumor immune response (J Clin Oncol 42, 2024 (suppl 16; abstr 2650, NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04465487 Phase I Cemiplimab + REGN6569 Study of REGN6569 and Cemiplimab in Adult Patients With Advanced Solid Tumor Malignancies Recruiting USA | ESP 0


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