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Therapy Name ONC206
Synonyms
Therapy Description

ONC206 is an imipridone derivative that activates the stress response pathway, inhibits the p38MAPK/ERK and c-Myc pathways, glycolysis and oxidative phosphorylation, potentially leading to inhibition of cell proliferation, migration and tumor growth (PMID: 28489985, PMID: 32867127, PMID: 30037819)

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ONC206 ONC 206|ONC-206 ONC206 is an imipridone derivative that activates the stress response pathway, inhibits the p38MAPK/ERK and c-Myc pathways, glycolysis and oxidative phosphorylation, potentially leading to inhibition of cell proliferation, migration and tumor growth (PMID: 28489985, PMID: 32867127, PMID: 30037819)

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04541082 Phase I ONC206 Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms Recruiting USA 0
NCT04732065 Phase I ONC206 ONC206 for Treatment of Newly Diagnosed or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant Brain Tumors (PNOC 023) Recruiting USA | CHE 0


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