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Therapy Detail
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| Therapy Name | ONC206 |
| Synonyms | |
| Therapy Description |
ONC206 is an imipridone derivative that activates the stress response pathway, inhibits the p38MAPK/ERK and c-Myc pathways, glycolysis and oxidative phosphorylation, potentially leading to inhibition of cell proliferation, migration and tumor growth (PMID: 28489985, PMID: 32867127, PMID: 30037819) |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ONC206 | ONC 206|ONC-206 | ONC206 is an imipridone derivative that activates the stress response pathway, inhibits the p38MAPK/ERK and c-Myc pathways, glycolysis and oxidative phosphorylation, potentially leading to inhibition of cell proliferation, migration and tumor growth (PMID: 28489985, PMID: 32867127, PMID: 30037819) |
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04732065 | Phase I | ONC206 | ONC206 for Treatment of Newly Diagnosed or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant Brain Tumors (PNOC 023) | Recruiting | USA | CHE | 0 |
| NCT04541082 | Phase I | ONC206 | Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms | Recruiting | USA | 0 |
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