Therapy Detail
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| Therapy Name | AMG 910 |
| Synonyms | |
| Therapy Description |
AMG 910 is a bispecific T-cell engager (BiTE) that targets CLDN18.2 expressed on tumor cells, and the CD3 antigen found on cytotoxic T cell lymphocytes, potentially resulting in T cell directed lysis of tumor cells (Ann Oncol. 2020 Sep 1;31(Supple. 4):S928-S929). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AMG 910 | AMG-910|AMG910|Bispecific Antibody AMG 910 | CLDN18.2 Antibody 23 | AMG 910 is a bispecific T-cell engager (BiTE) that targets CLDN18.2 expressed on tumor cells, and the CD3 antigen found on cytotoxic T cell lymphocytes, potentially resulting in T cell directed lysis of tumor cells (Ann Oncol. 2020 Sep 1;31(Supple. 4):S928-S929). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04260191 | Phase I | AMG 910 | Study of AMG 910 in Subjects With CLDN18.2-Positive Gastric and Gastroesophageal Junction Adenocarcinoma | Terminated | USA | NLD | FRA | ESP | DEU | AUT | 3 |
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