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Therapy Name CD19-PD-1/CD28-CAR T cells
Synonyms
Therapy Description

CD19-PD-1/CD28-CAR T cells consist of autologous T-lymphomcytes engineered to produce a chimeric antigen receptor (CAR) with an anti-CD19 fragment and a PD-1/CD28 chimeric switch-receptor, which may lead to potential cytotoxic activity against tumor cells expressing PD-L1 (PMID: 33028589).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CD19-PD-1/CD28-CAR T cells CD19-PD-1/CD28-CAR T cells consist of autologous T-lymphomcytes engineered to produce a chimeric antigen receptor (CAR) with an anti-CD19 fragment and a PD-1/CD28 chimeric switch-receptor, which may lead to potential cytotoxic activity against tumor cells expressing PD-L1 (PMID: 33028589).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 over exp B-cell lymphoma sensitive CD19-PD-1/CD28-CAR T cells Preclinical - Cell line xenograft Actionable In a preclinical study, CD19-PD-1/CD28 CAR T cell treatment induced dose-dependent cytotoxicity against a B cell lymphoma cell line with CD274 overexpression in culture, and resulted in greater inhibition of tumor growth in a cell line xenograft model compared to treatment with anti-CD19 CAR T cells alone or combined with an anti-PD-1 antibody (PMID: 33028589). 33028589
CD274 positive diffuse large B-cell lymphoma predicted - sensitive CD19-PD-1/CD28-CAR T cells Case Reports/Case Series Actionable In a Phase Ib trial, CD19-PD-1/CD28-CAR T cell treatment in two patients with CD274 positive diffuse large B-cell lymphoma resulted in complete remission (CR) after 3 months, however, disease progression was observed in one patient after 2 months, while the other patient achieved persistent CR. (PMID: 33028589). 33028589

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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