Therapy Detail
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| Therapy Name | Sym021 + Sym024 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Sym021 | Sym-021|Sym 021 | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | Sym021 is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3822, PMID: 31046547, PMID: 31754392). | |
| Sym024 | Sym-024|Sym 024|S095024 | CD73 Antibody 14 | Sym024 is a monoclonal antibody against CD73, which may inhibit the conversion of AMP to adenosine, reducing adenosine-mediated immunosuppression (Cancer Res (2024) 84 (6_Supplement): 3737, NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04672434 | Phase I | Sym021 + Sym024 Sym024 | Sym024 Monotherapy and in Combination With Sym021 in Patients With Advanced Solid Tumor Malignancies | Completed | USA | CAN | 0 |
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