Therapy Detail
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| Therapy Name | AMG 256 |
| Synonyms | |
| Therapy Description |
AMG 256 is a fusion protein comprising of mutated IL-21 fused to an antibody targeting PD-1, which binds to and inhibits PD-1 signaling, potentially leading to the restoration of the T-cell mediated immune response (NCI Thesaurus, Journal for ImmunoTherapy of Cancer 2020;8) |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AMG 256 | AMG-256|AMG256|Latikafusp | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 136 | AMG 256 is a fusion protein comprising of mutated IL-21 fused to an antibody targeting PD-1, which binds to and inhibits PD-1 signaling, potentially leading to the restoration of the T-cell mediated immune response (NCI Thesaurus, Journal for ImmunoTherapy of Cancer 2020;8) |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04362748 | Phase I | AMG 256 | Study of AMG 256 in Adult Subjects With Advanced Solid Tumors | Completed | USA | ESP | BEL | AUS | 0 |
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