Therapy Detail
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| Therapy Name | ASTX030 + Azacitidine |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ASTX030 | ASTX 030|ASTX-030|AZA/CDZ Combination|Cedazuridine + Azacitidine | ASTX030 is a combination of azacitidine and cedazuridine, which may lead to inhibition of cell proliferation of tumor cells (Blood (2019) 134 (Supplement_1): 1376). | ||
| Azacitidine | Vidaza | azacytidine|CC-486|5-azacytidine|5-AC|U-18496|Onureg | DNMT inhibitor (Pan) 5 | Vidaza (azacitidine) is a cytidine analog that incorporates into DNA and RNA and binds to DNA methyltransferases (DNMTs), resulting in DNMT degradation and decreased DNA methylation, and leading to increased tumor cell death (PMID: 28159832, PMID: 28067760). Vidaza (azacitidine) is FDA-approved for use in patients with some subtypes of myelodysplastic syndrome and Onureg (azacitidine) is FDA approved for use in continued treatment of acute myeloid leukemia(FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04256317 | Phase II | ASTX030 ASTX030 + Azacitidine + Venetoclax ASTX030 + Azacitidine ASTX030 + Azacitidine + Cedazuridine | A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study) (AZTOUND) | Recruiting | USA | POL | ITA | HUN | GBR | FRA | ESP | DEU | CZE | CAN | 0 |
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