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Therapy Name MCLA-129
Synonyms
Therapy Description

MCLA-129 is a bispecific antibody that binds to and inhibits EGFR and MET, which may lead to inhibition of cell proliferation and tumor regression (Mol Cancer Ther 2019;18(12 Suppl):Abstract nr LB-C07).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MCLA-129 MCLA 129|MCLA129 EGFR Inhibitor (Pan) 62 MET Antibody 31 MCLA-129 is a bispecific antibody that binds to and inhibits EGFR and MET, which may lead to inhibition of cell proliferation and tumor regression (Mol Cancer Ther 2019;18(12 Suppl):Abstract nr LB-C07).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04868877 Phase Ib/II MCLA-129 + Osimertinib MCLA-129 Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination Recruiting USA | NLD | ITA | FRA | ESP | DEU | BEL 2


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