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Therapy Name IBI110 + Sintilimab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
IBI110 IBI 110|IBI-110|negalstobart LAG3 Antibody 18 IBI110 is a monoclonal antibody that targets LAG3 on tumor infiltrating lymphocytes, and prevents the interaction between LAG3 and MHC II molecules expressed on antigen-presenting cells and tumor cells, potentially leading to increased cytotoxic T lymphocyte-mediated antitumor immune response and inhibition of tumor growth (NCI Drug Dictionary).
Sintilimab IBI308|Tyvyt Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 Sintilimab (IBI308) is a monoclonal antibody that targets PD-1 (PDCD1), potentially resulting in enhanced anti-tumor immune response (PMID: 29300693, PMID: 29900038, PMID: 32656988).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05572463 Phase Ib/II IBI110 + Sintilimab A Platform Study of Novel Immunotherapy Products in Participants With Previously Treated Unresectable or Metastatic Cutaneous Melanoma Withdrawn USA | GBR | FRA | ESP | DEU | CHE | AUS 0


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