Therapy Detail
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| Therapy Name | SHR-1701 |
| Synonyms | |
| Therapy Description |
SHR-1701 is a monoclonal anti-PD-L1 antibody fused to the extracellular domain of Tgfbr2, which may trap TGFbeta and block TGFbeta-mediated immune suppression, leading to enhanced response to PD-L1 inhibition (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 9055-9055). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| SHR-1701 | SHR 1701|SHR1701|Retlirafusp Alfa | Immune Checkpoint Inhibitor 150 PD-L1 Inhibitor 15 TGFB inhibitor 5 | SHR-1701 is a monoclonal anti-PD-L1 antibody fused to the extracellular domain of Tgfbr2, which may trap TGFbeta and block TGFbeta-mediated immune suppression, leading to enhanced response to PD-L1 inhibition (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 9055-9055). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04324814 | Phase I | SHR-1701 | A Trial of SHR-1701 in Subjects With Advanced Solid Tumors | Completed | AUS | 0 |
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