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Therapy Name SHR-1701
Synonyms
Therapy Description

SHR-1701 is a monoclonal anti-PD-L1 antibody fused to the extracellular domain of Tgfbr2, which may trap TGFbeta and block TGFbeta-mediated immune suppression, leading to enhanced response to PD-L1 inhibition (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 9055-9055).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SHR-1701 SHR 1701|SHR1701|Retlirafusp Alfa Immune Checkpoint Inhibitor 149 PD-L1 Inhibitor 13 TGFB inhibitor 5 SHR-1701 is a monoclonal anti-PD-L1 antibody fused to the extracellular domain of Tgfbr2, which may trap TGFbeta and block TGFbeta-mediated immune suppression, leading to enhanced response to PD-L1 inhibition (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 9055-9055).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04324814 Phase I SHR-1701 A Trial of SHR-1701 in Subjects With Advanced Solid Tumors Completed AUS 0


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