Therapy Detail
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| Therapy Name | ABBV-637 + Docetaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ABBV-637 | ABBV637|ABBV 637 | EGFR Antibody 72 | ABBV-637 is an antibody-drug conjugate (ADC) comprising an antibody targeting EGFR linked to a BCL-XL inhibitor, which potentially induces antitumor activity (Ann Oncol (2023) 34 (suppl_2): S759). | |
| Docetaxel | Taxotere | RP56976 | Antimicrotubule Agent 14 | Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (PMID: 32496783, PMID: 32366558). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04721015 | Phase I | ABBV-637 + Docetaxel ABBV-637 + Osimertinib ABBV-637 | Study of Intravenous (IV) ABBV-637 Alone or in Combination With IV Docetaxel/Osimertinib to Assess Adverse Events and Change in Disease Activity in Adult Participants With Relapsed/Refractory (R/R) Solid Tumors | Active, not recruiting | USA | ISR | FRA | ESP | AUS | 3 |
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