Therapy Detail
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| Therapy Name | Docetaxel + Mirzotamab clezutoclax + Paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Docetaxel | Taxotere | RP56976 | Antimicrotubule Agent 14 | Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (PMID: 32496783, PMID: 32366558). |
| Mirzotamab clezutoclax | ABBV-155|ABBV 155|ABBV155 | BCL-XL inhibitor 14 CD276 Antibody 16 | Mirzotamab clezutoclax (ABBV-155) is an antibody-drug conjugate (ADC) consisting of a BCL-XL inhibitor linked to a monoclonal antibody targeted against CD276 (B7H3), which may have antitumor activity (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 3015). | |
| Paclitaxel | Taxol | 7-Epipaclitaxel | Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 | Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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