Therapy Detail
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| Therapy Name | MK-1308A + MK-4830 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| MK-1308A | Pembrolizumab/Quavonlimab|MK1308A|MK 1308A | CTLA4 Antibody 33 Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | MK-1308A is a coformulation of Pembrolizumab and Quavonlimab, which potentially induces antitumor activity (Cancer Res (2024) 84 (7_Supplement): CT256). | |
| MK-4830 | MK4830|MK 4830 | Immune Checkpoint Inhibitor 150 LILRB2 Antibody 12 | MK-4830 is a monoclonal antibody that targets LILRB2 (ILT4), which may relieve LILRB2 (ILT4)-mediated immunosuppression in the tumor microenvironment and enhance antitumor activity (PMID: 34598945, NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04938817 | Phase Ib/II | Lenvatinib + MK-1308A MK-1308A MK-4280A MK-1308A + MK-4830 | Safety and Efficacy Study of Pembrolizumab (MK-3475) in Combination With Investigational Agents for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98) | Recruiting | USA | POL | ITA | ISR | HUN | ESP | CHE | CAN | AUT | AUS | 2 |
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