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Therapy Name PCLX-001
Synonyms
Therapy Description

PCLX-001 inhibits the N-myristoyl-transferases NMT1 and NMT2, potentially resulting in inhibition of early B-cell receptor signaling and degradation of pERK, c-Myc, NFkappaB and CREB, which may lead to tumor cell apoptosis, decreased cell proliferation, and inhibition of tumor growth (PMID: 33093447).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PCLX-001 PCLX 001|PCLX001|Zelenirstat PCLX-001 inhibits the N-myristoyl-transferases NMT1 and NMT2, potentially resulting in inhibition of early B-cell receptor signaling and degradation of pERK, c-Myc, NFkappaB and CREB, which may lead to tumor cell apoptosis, decreased cell proliferation, and inhibition of tumor growth (PMID: 33093447).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04836195 Phase I PCLX-001 Study of PCLX-001 in R/R Advanced Solid Malignancies and B-cell Lymphoma Completed CAN 0
NCT06613217 Phase I PCLX-001 Study of Oral PCLX-001 in R/R Acute Myeloid Leukemia Recruiting USA 0


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