Therapy Detail
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| Therapy Name | Doxorubicin + TTI-621 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Doxorubicin | Adriamycin | Adria|ADR|Doxorubicin hydrochloride|Hydroxydaunorubicin | Chemotherapy - Anthracycline 13 TOPO2 inhibitor 5 | Adriamycin (doxorubicin) is an anthracycline chemotherapeutic, in a non-liposomal formulation, which intercalates into DNA and inhibits topoisomerase II (PMID: 24367159). Doxorubicin is FDA approved for multiple cancer types (FDA.gov). |
| TTI-621 | SIRPalpha-Fc|TTI621|TTI 621|ontorpacept | CD47 Antibody 31 Immune Checkpoint Inhibitor 150 | TTI-621 (ontorpacept) is a fusion protein consisting of the CD47 binding domain of SIRPalpha linked to the IgG1 Fc domain, which potentially enhances phagocytosis of tumor cells and inhibits tumor growth (PMID: 27856600, PMID: 33451977). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04996004 | Phase Ib/II | Doxorubicin + TTI-621 | A Trial of TTI-621 in Combination With Doxorubicin in Patients With Leiomyosarcoma | Terminated | USA | 0 |
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