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Therapy Name APG101
Synonyms
Therapy Description

APG101, a glycosylated fusion protein comprised of the CD95 extracellular domain and of the IgG1 Fc domain, which binds to CD95L and prevents binding to CD95, potentially leading to decreased tumor cell invasion and increased radiotherapy efficacy (PMID: 29453321, PMID: 25850884, PMID: 22446296).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
APG101 APG-101|APG 101|Asunercept|Apocept|CAN008|CAN-008 APG101, a glycosylated fusion protein comprised of the CD95 extracellular domain and of the IgG1 Fc domain, which binds to CD95L and prevents binding to CD95, potentially leading to decreased tumor cell invasion and increased radiotherapy efficacy (PMID: 29453321, PMID: 25850884, PMID: 22446296).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03158389 Phase Ib/II Vismodegib Alectinib Idasanutlin Temsirolimus Atezolizumab Palbociclib APG101 NCT Neuro Master Match - N²M² (NOA-20) (N²M²) Completed DEU 0


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