Therapy Detail
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| Therapy Name | Glecirasib |
| Synonyms | |
| Therapy Description |
Glecirasib (JAB-21822) is an inhibitor of KRAS G12C, with potential antitumor activity (J Clin Oncol 40, no. 16_suppl (June 01, 2022) 3089-3089). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Glecirasib | JAB21822|JAB 21822|JAB-21822 | KRAS G12C inhibitor 36 | Glecirasib (JAB-21822) is an inhibitor of KRAS G12C, with potential antitumor activity (J Clin Oncol 40, no. 16_suppl (June 01, 2022) 3089-3089). |
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| HRAS G12C | Advanced Solid Tumor | sensitive | Glecirasib | Preclinical - Cell culture | Actionable | In a preclinical study, Glecirasib (JAB-21822) treatment inhibited viability of cells expressing HRAS G12C in culture (PMID: 40304209). | 40304209 |
| NRAS G12C | Advanced Solid Tumor | sensitive | Glecirasib | Preclinical - Cell culture | Actionable | In a preclinical study, Glecirasib (JAB-21822) treatment inhibited viability of cells expressing NRAS G12C in culture (PMID: 40304209). | 40304209 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05002270 | Phase Ib/II | Cetuximab + Glecirasib Glecirasib | JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation | Unknown status | USA | 0 |
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