Therapy Detail
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| Therapy Name | Anlotinib + Cadonilimab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Anlotinib | AL3818|AL-3818|AL 3818 | FGFR Inhibitor (Pan) 26 KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 RET Inhibitor 53 VEGFR2 Inhibitor 37 VEGFR3 Inhibitor 6 | Anlotinib (AL-3818) inhibits KDR (VEGFR2) and VEGFR3, FGFR1-4, PDGFRA/B, KIT, and RET, which may inhibit angiogenesis and tumor cell growth (PMID: 27716285, PMID: 32547218, PMID: 32724339). | |
| Cadonilimab | AK-104|AK 104|AK104 | CTLA4 Antibody 32 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 | Cadonilimab is a bispecific antibody that targets CD274 (PD-L1) and CTLA-4, potentially resulting in enhanced anti-tumor immune response (PMID: 36872527). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 positive | lung non-small cell carcinoma | predicted - sensitive | Anlotinib + Cadonilimab | Phase Ib/II | Actionable | In a Phase Ib/II trial, combination treatment with Cadonilimab and Anlotinib (AL-3818) demonstrated antitumor activity in patients with CD274 (PD-L1) positive (TPS >= 1%) non-small cell lung cancer, and led to an objective response rate of 62.5% (5/8) and a disease control rate of 100% (8/8). (Annals of Oncology 32 (2021): S1006; NCT04646330). | detail... |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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