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Therapy Detail
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| Therapy Name | LVGN3616 + LVGN6051 + LVGN7409 + Nab-paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| LVGN3616 | LVGN-3616|LVGN 3616|pradusinstobart | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 124 | LVGN3616 is a humanized monoclonal antibody that targets PD-1 (PDCD1), potentially resulting in restoration of T-cell mediated immune response (NCI Thesaurus). | |
| LVGN6051 | LVGN-6051|LVGN 6051|Exlinkibart | TNFRSF9 Antibody 32 | LVGN6051 is a monoclonal antibody that targets 4-1BB (CD137) and acts as an agonist in the presence of Fc-gammaRIIB, potentially resulting in decreased tumor growth (PMID: 31105267). | |
| LVGN7409 | LVGN-7409|LVGN 7409 | CD40 Antibody 15 | LVGN7409 is an agonist antibody targeting CD40, which may lead to activation of downstream signaling and T-cell activity (NCI Drug Dictionary). | |
| Nab-paclitaxel | Abraxane | ABI-007|Paclitaxel Protein-bound | Chemotherapy - Taxane 3 | Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05075993 | Phase I | Bevacizumab + Cyclophosphamide + LVGN3616 + LVGN6051 + LVGN7409 LVGN3616 + LVGN6051 + LVGN7409 + Nab-paclitaxel Bevacizumab + Cyclophosphamide + LVGN3616 + LVGN6051 LVGN3616 + LVGN6501 + Nab-paclitaxel | Study of LVGN3616 and LVGN6501±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors | Active, not recruiting | USA | 0 |
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