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Therapy Detail
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| Therapy Name | NDI-101150 |
| Synonyms | |
| Therapy Description |
NDI-101150 inhibits MAP4K1 (HPK1), which may prevent immunosuppression in the tumor microenvironment, potentially inducing a cytotoxic T-lymphocyte (CTL) response against tumor cells and resulting in antitumor activity (J Clin Oncol 42, 2024 (suppl 16; abstr 3083); NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| NDI-101150 | NDI 101150|NDI101150 | MAP4K1 Inhibitor 8 | NDI-101150 inhibits MAP4K1 (HPK1), which may prevent immunosuppression in the tumor microenvironment, potentially inducing a cytotoxic T-lymphocyte (CTL) response against tumor cells and resulting in antitumor activity (J Clin Oncol 42, 2024 (suppl 16; abstr 3083); NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05128487 | Phase Ib/II | NDI-101150 NDI-101150 + Pembrolizumab | A Study of NDI 1150-101 in Patients With Solid Tumors | Active, not recruiting | USA | 0 |
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