Therapy Detail

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Therapy Name Paclitaxel + PRS-343 + Ramucirumab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PRS-343 HER2 (ERBB2) Antibody 76 TNFRSF9 Antibody 32 PRS-343 is a bispecific antibody targeting both CD137 (4-1BB) and Erbb2 (Her2), resulting in enhanced anti-tumor immune response against Erbb2 (Her2)-positive tumor cells (Eur J Cancer, Dec 2016, 69 (Suppl. 1): S99, abstract 301, PMID: 31138587).
Paclitaxel Taxol 7-Epipaclitaxel Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary).
Ramucirumab Cyramza LY3009806 VEGFR2 Antibody 4 Cyramza (ramucirumab) is a monoclonal antibody, which binds and inhibits VEGFR2 (KDR) resulting in decreased angiogenesis (PMID: 24094768). Cyramza (ramucirumab) is FDA approved for use as a monotherapy or in combination with paclitaxel in patients with gastric or gastroesophageal junction adenocarcinoma who progressed on chemotherapy, in combination with erlotinib as first-line therapy in patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion mutations or L858R, in combination with decetaxel in patients with NSCLC who progressed on prior therapy, in combination with FOLFIRI in patients with colorectal cancer who progressed on prior therapy, and as monotherapy in patients with hepatocellular carcinoma who have received sorafenib (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05190445 Phase II PRS-343 + Tucatinib Paclitaxel + PRS-343 + Ramucirumab Cinrebafusp Alfa in Combination With Ramucirumab and Paclitaxel in HER2-High Gastric or GEJ Adenocarcinoma and in Combination With Tucatinib in HER2-Low Gastric or GEJ Andenocarinoma Active, not recruiting USA 1


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