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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cyclophosphamide Cytoxan CPM Chemotherapy - Alkylating 18 Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).
Cytarabine Cytosar-U Ara-C Cytosar-U (cytarabine) is a cytidine analog that, when incorporated into DNA, inhibits DNA synthesis and repair (PMID: 32524309).
Dexamethasone Adexone Desametasone
Etoposide Vepesid EPEG|Eposin|VP-16|VP-16-213 TOPO2 inhibitor 5 Vepesid (etoposide) binds to and inhibits DNA topoisomerase II, resulting in accumulated DNA damage, inhibition of replication, and cell death (NCI Drug Dictionary).
Hydrocortisone Cortisol
Leucovorin Wellcovorin Calcium folinate|Calcium citrovorum factor|folinic acid Chemotherapy - Antimetabolite 14 Wellcovorin (leucovorin) is a metabolite of folate that enhances the efficacy of fluoruracil (PMID: 32490554).
Mercaptopurine Purixan 6 MP|Purinethol
Methotrexate Abitrexate Amethopterin Chemotherapy - Antimetabolite 14 Methotrexate is an antimetabolite, which inhibits DHFR resulting in decreased immune function and antineoplastic activity and is FDA approved for psoriasis, RA, and several cancers including choriocarcinoma, AML, lung, head and neck and epidermoid (FDA.gov).
Vincristine Sulfate Oncovin 22-Oxovincaleukoblastine|vincristine Oncovin (vincristine) binds microtubules and prevents mitotic spindle formation, resulting in cell-cycle arrest (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05192889 Phase Ib/II Dexamethasone + Pegaspargase + Vincristine Sulfate Blinatumomab + Cytarabine + Dexamethasone + Hydrocortisone + Methotrexate + Venetoclax Cyclophosphamide + Cytarabine + Dexamethasone + Etoposide + Hydrocortisone + Leucovorin + Mercaptopurine + Methotrexate + Vincristine Sulfate Cytarabine + Dexamethasone + Hydrocortisone + Mercaptopurine + Methotrexate + Vincristine Sulfate Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Methotrexate + Navitoclax + Pegaspargase + Venetoclax Dasatinib + Dexamethasone + Pegaspargase + Vincristine Sulfate Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Mercaptopurine + Methotrexate + Vincristine Sulfate Cytarabine + Dexamethasone + Hydrocortisone + Leucovorin + Methotrexate + Navitoclax + Pegaspargase + Venetoclax + Vincristine Sulfate Cyclophosphamide + Cytarabine + Dasatinib + Dexamethasone + Etoposide + Hydrocortisone + Leucovorin + Mercaptopurine + Methotrexate + Vincristine Sulfate Cytarabine + Dexamethasone + Hydrocortisone + Methotrexate + Navitoclax + Pegaspargase + Venetoclax Cytarabine + Hydrocortisone + Leucovorin + Mercaptopurine + Methotrexate Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Leucovorin + Methotrexate + Navitoclax + Pegaspargase + Venetoclax + Vincristine Sulfate Blinatumomab + Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Methotrexate + Venetoclax Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax Active, not recruiting USA 0


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