Therapy Detail
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| Therapy Name | Evofosfamide |
| Synonyms | |
| Therapy Description |
Evofosfamide (TH-302) is a hypoxia-activated prodrug that releases a DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors, potentially providing antineoplastic activity with reduced systemic toxicity (PMID: 32787454, PMID: 31431383). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Evofosfamide | TH-302 | Chemotherapy - Alkylating 18 | Evofosfamide (TH-302) is a hypoxia-activated prodrug that releases a DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors, potentially providing antineoplastic activity with reduced systemic toxicity (PMID: 32787454, PMID: 31431383). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PALB2 dec exp | triple-receptor negative breast cancer | sensitive | Evofosfamide | Preclinical | Actionable | In a preclinical study, knockdown of PALB2 enhanced growth inhibition by Evofosfamide (TH-302) in triple-negative breast cancer cell lines in culture (PMID: 25193512). | 25193512 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT01522872 | Phase Ib/II | Evofosfamide Bortezomib | Open-label Study of TH-302 and Dexamethasone With or Without Bortezomib in Subjects With Relapsed/Refractory Multiple Myeloma | Unknown status | USA | 0 |
| NCT01403610 | Phase II | Bevacizumab + Evofosfamide Evofosfamide | Safety and Efficacy Study of TH-302 CNS Penetration in Recurrent High Grade Astrocytoma Following Bevacizumab | Completed | USA | 0 |
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