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Therapy Detail
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| Therapy Name | MGC018 + MGD019 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| MGC018 | CD276 Antibody 18 | MGC018 is a humanized monoclonal anti-B7-H3 (CD276) antibody in conjugation with a cytotoxic agent (vc-seco-DUBA), which may specifically target B7-H3-expressing tumor cells (Cancer Res 2018;78(13 Suppl):Abstract nr 820, PMID: 32967924). | ||
| MGD019 | MGD-019|MGD 019|AEX-1344|AEX1344|lorigerlimab | CTLA4 Inhibitor 4 Immune Checkpoint Inhibitor 149 | MGD019 is a tetravalent, dual-affinity re-targeting (DART) protein that potentially inhibits PD-1 (PDCD1) and CTLA4, resulting in enhanced immune response against cancer cells expressing PD-1 and CTLA4 (Keystone Symposia Conference, 2019, Feb. 18-22, Abs nr: 1012). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05293496 | Phase I | MGC018 + MGD019 | A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors | Active, not recruiting | USA | 0 |
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