Therapy Detail
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| Therapy Name | AK119 + Cadonilimab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AK119 | AK 119|AK-119|Dresbuxelimab | CD73 Antibody 14 | AK119 is a monoclonal antibody targeting CD73, which may lead to decreased adenosine via inhibition of the conversion of adenosine monophosphate (AMP) to adenosine, potentially resulting in anti-tumor activity (J Clin Oncol 2021 39:15_suppl, TPS2675). | |
| Cadonilimab | AK-104|AK 104|AK104 | CTLA4 Antibody 33 Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | Cadonilimab is a bispecific antibody that targets CD274 (PD-L1) and CTLA-4, potentially resulting in enhanced anti-tumor immune response (PMID: 36872527). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04572152 | Phase I | AK119 + Cadonilimab | A Study of AK119 (Anti-CD73) in Combination With AK104 in Subjects With Advanced Solid Tumors | Completed | AUS | 0 |
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