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Therapy Name HP518
Synonyms
Therapy Description

HP518 is a proteolysis-targeted chimera (PROTAC) that induces degradation of wild-type and mutant forms of the androgen receptor (AR), which potentially induces antitumor activity (J Clin Oncol 2024 42:4_suppl, 124; J Clin Oncol 42 2024 42:16_suppl, 5058).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
HP518 HP 518|HP-518 Hormone - Anti-androgens 54 HP518 is a proteolysis-targeted chimera (PROTAC) that induces degradation of wild-type and mutant forms of the androgen receptor (AR), which potentially induces antitumor activity (J Clin Oncol 2024 42:4_suppl, 124; J Clin Oncol 42 2024 42:16_suppl, 5058).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05252364 Phase I HP518 A Study to Assess the Safety, Pharmacokinetics, and Anti-Tumor Activity of Oral HP518 in Patients With Metastatic Castration-Resistant Prostate Cancer Completed AUS 0


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