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Therapy Name Ritlecitinib
Synonyms
Therapy Description

Ritlecitinib (PF-06651600) is a covalent Jak3 inhibitor, which reduces downstream signaling and potentially inhibits tumor cell viability (PMID: 35411095).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ritlecitinib PF-06651600|PF06651600|PF 06651600 JAK3 Inhibitor 6 Ritlecitinib (PF-06651600) is a covalent Jak3 inhibitor, which reduces downstream signaling and potentially inhibits tumor cell viability (PMID: 35411095).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK3 M511I T-cell acute lymphoblastic leukemia sensitive Ritlecitinib Preclinical - Patient cell culture Actionable In a preclinical study, Ritlecitinib (PF-06651600) treatment inhibited downstream signaling, induced apoptosis, and reduced cell viability of patient-derived T-cell acute lymphoblastic leukemia cell lines harboring JAK3 M511I (PMID: 35411095). 35411095

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05879458 Phase II Ritlecitinib Ritlecitinib in CTCL Recruiting USA 0


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