Therapy Detail

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Therapy Name MCARH109 + MCARH125
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MCARH109 MCARH-109|MCARH 109 MCARH109 are autologous T lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting GPRC5D and CD137 (4-1BB), which may selective recognize GPRC5D expressing tumor cells and activate anti-tumor immune response (PMID: 36170501).
MCARH125 MCARH-125|MCARH 125 MCARH125 are autologous T-cells engineered to express a chimeric antigen receptor (CAR) that targets the B-cell maturation antigen (BCMA; TNFRSF17), which potentially induce cytotoxicity in tumor cells expressing BCMA (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05431608 Phase I MCARH109 + MCARH125 A Study of MCARH109 and MCARH125 in People With Multiple Myeloma Recruiting USA 0


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