Therapy Detail
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| Therapy Name | AMG193 |
| Synonyms | |
| Therapy Description |
AMG193 inhibits protein arginine methyltransferase 5 (PRMT5), potentially leading to inhibition of tumor cell proliferation (NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AMG193 | AMG-193|AMG 193 | PRMT5 Inhibitor 20 | AMG193 inhibits protein arginine methyltransferase 5 (PRMT5), potentially leading to inhibition of tumor cell proliferation (NCI Drug Dictionary). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06593522 | Phase II | AMG193 | A Phase 2 Study of AMG 193 in Participants With MTAP-deleted Advanced NSCLC | Recruiting | USA | CAN | BRA | AUS | 6 |
| NCT06333951 | Phase I | AMG193 + Pembrolizumab AMG193 + Carboplatin + Pembrolizumab + Pemetrexed Disodium AMG193 AMG193 + Sotorasib AMG193 + Carboplatin + Paclitaxel + Pembrolizumab | AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) | Recruiting | USA | POL | NLD | ITA | GRC | FRA | ESP | DEU | CAN | BRA | BEL | AUT | AUS | 5 |
| NCT05094336 | Phase Ib/II | AMG193 AMG193 + Docetaxel | A Study of AMG 193 in Participants With Advanced MTAP-null Solid Tumors (MTAP) | Recruiting | USA | GBR | FRA | DEU | CHE | CAN | BEL | AUT | AUS | 5 |
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