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Therapy Detail

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Therapy Name HMBD-001
Synonyms
Therapy Description

HMBD-001 is a monoclonal antibody that binds ERBB3 (HER3) and prevents heterodimer formation, potentially inhibiting tumor growth (Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P197).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
HMBD-001 HMBD001|HMBD 001 HER3 (ERBB3) Antibody 23 HMBD-001 is a monoclonal antibody that binds ERBB3 (HER3) and prevents heterodimer formation, potentially inhibiting tumor growth (Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P197).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05919537 Phase Ib/II Docetaxel + HMBD-001 HMBD-001 Gemcitabine + HMBD-001 + Nab-paclitaxel Study of an Anti-HER3 Antibody, HMBD-001, With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutation Active, not recruiting AUS 0
NCT05057013 Phase Ib/II HMBD-001 A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours Recruiting GBR 0


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