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Therapy Name Zurletrectinib
Synonyms
Therapy Description

Zurletrectinib is a pan-NTRK inhibitor with activity against resistance mutations, which potentially reduces tumor cell proliferation and tumor growth (PMID: 38902532).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Zurletrectinib ICP723|ICP 723|ICP-723 Trk Receptor Inhibitor (Pan) 33 Zurletrectinib is a pan-NTRK inhibitor with activity against resistance mutations, which potentially reduces tumor cell proliferation and tumor growth (PMID: 38902532).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 fusion Advanced Solid Tumor predicted - sensitive Zurletrectinib Case Reports/Case Series Actionable In a Phase I trial, Zurletrectinib treatment was well tolerated and resulted in an overall response rate of 66.7% (4/6, all partial responses) and a disease control rate of 100% (6/6) in patients with NTRK fusion-positive advanced solid tumors, including one partial response with a measurable decrease in the brain lesion (J Clin Oncol 40, no. 16_suppl (June 01, 2022) 3106; NCT04685226). detail...
NTRK1 fusion Advanced Solid Tumor predicted - sensitive Zurletrectinib Case Reports/Case Series Actionable In a Phase I trial, Zurletrectinib treatment was well tolerated and resulted in an overall response rate of 66.7% (4/6, all partial responses) and a disease control rate of 100% (6/6) in patients with NTRK fusion-positive advanced solid tumors, including one partial response with a measurable decrease in the brain lesion (J Clin Oncol 40, no. 16_suppl (June 01, 2022) 3106; NCT04685226). detail...

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05537987 Phase I Zurletrectinib Evaluate the Safety, Tolerability, and Pharmacokinetics of ICP-723 in Patients With Advanced Solid Tumors Unknown status USA 0


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