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Therapy Name TQ-B3101
Synonyms
Therapy Description

TQ-B3101 inhibits ROS1, ALK, and MET, potentially resulting in decreased tumor growth (PMID: 35115931).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TQ-B3101 TQ B3101|TQB3101|Unecritinib ALK Inhibitor 33 MET Inhibitor 59 ROS1 Inhibitor 22 TQ-B3101 inhibits ROS1, ALK, and MET, potentially resulting in decreased tumor growth (PMID: 35115931).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK rearrange Advanced Solid Tumor predicted - sensitive TQ-B3101 Phase I Actionable In a Phase I trial, TQ-B3101 treatment was well tolerated and resulted in an objective response rate (ORR) of 62.5% (15/24) in patients with ALK-positive, ROS1-positive, or MET-amplified advanced solid tumors, with an ORR of 62.5% (5/8) in patients with brain metastases (J Clin Oncol 38, 2020 (suppl 15; abstr e21705); NCT03019276). detail...
ROS1 rearrange lung non-small cell carcinoma sensitive TQ-B3101 Phase Ib/II Actionable In a Phase I/II trial, TQ-B3101 treatment demonstrated safety and resulted in an objective response rate (ORR) of 80.2% (89/111, 1 complete response (CR), 88 partial (PR)), disease control rate (DCR) of 88.3%, median duration of response of 20.3 mo, median progression-free survival of 16.5 mo, and intracranial ORR of 72.7% (8/11, 1 CR, 7 PR) and DCR of 90.9% in patients with non-small cell lung cancer harboring ROS1 rearrangements (PMID: 37385995; NCT03019276, NCT03972189). 37385995
ROS1 rearrange Advanced Solid Tumor predicted - sensitive TQ-B3101 Case Reports/Case Series Actionable In a Phase I trial, TQ-B3101 treatment was well tolerated and resulted in an objective response rate (ORR) of 62.5% (15/24) in patients with ALK-positive, ROS1-positive, or MET-amplified advanced solid tumors, with an ORR of 62.5% (5/8) in patients with brain metastases (J Clin Oncol 38, 2020 (suppl 15; abstr e21705); NCT03019276). detail...

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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