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Therapy Detail

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Therapy Name Zongertinib
Synonyms
Therapy Description

Zongertinib is an ERBB2 (HER2) selective inhibitor with potential anti-tumor activity (J of Clin Oncol 40, no. 16_suppl (June 01, 2022) TPS9143, PMID: 36528522).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Zongertinib BI-1810631|BI1810631|BI 1810631 HER2 Inhibitor 43 Zongertinib is an ERBB2 (HER2) selective inhibitor with potential anti-tumor activity (J of Clin Oncol 40, no. 16_suppl (June 01, 2022) TPS9143, PMID: 36528522).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06151574 Phase III Cisplatin + Pembrolizumab + Pemetrexed Disodium Carboplatin + Pembrolizumab + Pemetrexed Disodium Zongertinib Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment Recruiting USA | SWE | POL | NOR | NLD | ITA | ISR | GBR | FRA | ESP | DEU | CAN | BRA | BEL | AUT | AUS 10
NCT04886804 Phase I Zongertinib Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene) Recruiting USA | SWE | NLD | ITA | ISR | GBR | FRA | ESP | DEU | BEL | AUT | AUS 6
NCT06581432 Phase II Zongertinib Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations Recruiting USA | NOR | NLD | ITA | FRA | ESP | DEU | CAN | BEL | AUS 4


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