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Therapy Name OTX-2002
Synonyms
Therapy Description

OTX-2002 is an mRNA therapeutic that targets the insulated genomic domain of the MYC gene and leads to decreased MYC mRNA and protein levels, potentially resulting in reduced cell proliferation of tumor cells and inhibition of tumor growth (Annals of Oncology 33 (2022): S355).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
OTX-2002 OTX2002|OTX 2002 OTX-2002 is an mRNA therapeutic that targets the insulated genomic domain of the MYC gene and leads to decreased MYC mRNA and protein levels, potentially resulting in reduced cell proliferation of tumor cells and inhibition of tumor growth (Annals of Oncology 33 (2022): S355).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05497453 Phase Ib/II OTX-2002 A Phase 1/2 Study to Evaluate OTX-2002 in Patients With Hepatocellular Carcinoma and Other Solid Tumor Types Known for Association With the MYC Oncogene (MYCHELANGELO I) Recruiting USA 4


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