Therapy Detail
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| Therapy Name | CC-91516 |
| Synonyms | |
| Therapy Description |
CC-91516 inhibits Erk1/2 and Nlk, which potentially inhibits Mapk signaling, induces apoptosis, and inhibits tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 1180). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CC-91516 | CC91516|CC 91516|CC0776314 | ERK Inhibitor (pan) 21 | CC-91516 inhibits Erk1/2 and Nlk, which potentially inhibits Mapk signaling, induces apoptosis, and inhibits tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 1180). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF act mut | Advanced Solid Tumor | predicted - sensitive | CC-91516 | Preclinical - Patient cell culture | Actionable | In a preclinical study, CC-91516 treatment induced apoptosis and inhibited viability of cancer cells harboring BRAF activating mutations, and inhibited ex vivo colony formation from patient-derived xenograft (PDX) models in culture (Cancer Res 2022;82(12_Suppl):Abstract nr 1180). | detail... |
| BRAF act mut | colorectal cancer | predicted - sensitive | CC-91516 | Preclinical - Biochemical | Actionable | In a preclinical study, CC-91516 inhibited Mapk signaling in BRAF-mutant colorectal cancer cells (Cancer Res 2022;82(12_Suppl):Abstract nr 1180). | detail... |
| CTNNB1 act mut | Advanced Solid Tumor | predicted - sensitive | CC-91516 | Preclinical - Patient cell culture | Actionable | In a preclinical study, CC-91516 treatment induced apoptosis and inhibited viability of cancer cells harboring CTNNB1 activating mutations, and inhibited ex vivo colony formation from patient-derived xenograft (PDX) models in culture (Cancer Res 2022;82(12_Suppl):Abstract nr 1180). | detail... |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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