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Therapy Name EG-70
Synonyms
Therapy Description

EG-70 consists of a DNA vector engineered to express interleukin-12 (IL-12) and a retinoic acid-inducible gene I protein (RIG-I; DDX58) activator in a nanoparticle-based formulation, which leads to increased levels of IL-12, and potentially results in activation of an antitumor immune response (Urologic Oncology, 42, Supplement, 2024, S48).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
EG-70 EG 70|EG70|Detalimogene voraplasmid EG-70 consists of a DNA vector engineered to express interleukin-12 (IL-12) and a retinoic acid-inducible gene I protein (RIG-I; DDX58) activator in a nanoparticle-based formulation, which leads to increased levels of IL-12, and potentially results in activation of an antitumor immune response (Urologic Oncology, 42, Supplement, 2024, S48).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04752722 Phase Ib/II EG-70 EG-70 in NMIBC Patients Who Are BCG-Unresponsive and High-Risk NMIBC Patients Who Have Been Incompletely Treated With BCG or Are BCG-Naïve (LEGEND STUDY) Recruiting USA | CAN 0


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