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Therapy Name | Thiostrepton |
Synonyms | |
Therapy Description |
Thiostrepton (RSO-021) inhibits mitochondrial thioredoxin-dependent peroxide reductase (PRX-3), potentially resulting in an increase in intracellular hydrogen peroxide and tumor cell death (NCI Drug Dictionary). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Thiostrepton | RSO-021|RSO 021|RSO021 | Thiostrepton (RSO-021) inhibits mitochondrial thioredoxin-dependent peroxide reductase (PRX-3), potentially resulting in an increase in intracellular hydrogen peroxide and tumor cell death (NCI Drug Dictionary). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT05278975 | Phase Ib/II | Thiostrepton | Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma | Recruiting | GBR | 0 |