Therapy Detail
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| Therapy Name | Thiostrepton |
| Synonyms | |
| Therapy Description |
Thiostrepton (RSO-021) inhibits mitochondrial thioredoxin-dependent peroxide reductase (PRX-3), potentially resulting in an increase in intracellular hydrogen peroxide and tumor cell death (NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Thiostrepton | RSO-021|RSO 021|RSO021 | Thiostrepton (RSO-021) inhibits mitochondrial thioredoxin-dependent peroxide reductase (PRX-3), potentially resulting in an increase in intracellular hydrogen peroxide and tumor cell death (NCI Drug Dictionary). |
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05278975 | Phase Ib/II | Thiostrepton | Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma | Recruiting | GBR | 0 |
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