Therapy Detail
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| Therapy Name | SGN-PDL1V |
| Synonyms | |
| Therapy Description |
SGN-PDL1V is an antibody-drug conjugate (ADC) comprised of a monoclonal antibody targeting CD274 (PD-L1) linked to monomethyl auristatin E (MMAE), which potentially induces cytotoxicity, immune activation, and inhibition of tumor growth (J of Clin Oncol 40, no. 16_suppl (June 01, 2022) TPS3154). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| SGN-PDL1V | SGNPDL1V|SGN PDL1V|PF-08046054|PF08046054|PF 08046054 | PD-L1/PD-1 antibody 132 | SGN-PDL1V is an antibody-drug conjugate (ADC) comprised of a monoclonal antibody targeting CD274 (PD-L1) linked to monomethyl auristatin E (MMAE), which potentially induces cytotoxicity, immune activation, and inhibition of tumor growth (J of Clin Oncol 40, no. 16_suppl (June 01, 2022) TPS3154). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05208762 | Phase I | Pembrolizumab + SGN-PDL1V SGN-PDL1V | A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors | Recruiting | USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | 2 |
| NCT07144280 | Phase III | Docetaxel SGN-PDL1V | A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC) | Recruiting | USA | 4 |
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