Therapy Detail
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| Therapy Name | MT-6402 |
| Synonyms | |
| Therapy Description |
MT-6402 is an engineered toxin body that targets CD274 (PD-L1), potentially leading to killing of tumor cells expressing CD274 (PD-L1) and inhibition of tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr CT152). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| MT-6402 | MT 6402|MT6402 | PD-L1 Inhibitor 14 | MT-6402 is an engineered toxin body that targets CD274 (PD-L1), potentially leading to killing of tumor cells expressing CD274 (PD-L1) and inhibition of tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr CT152). |
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 positive | lung non-small cell carcinoma | predicted - sensitive | MT-6402 | Case Reports/Case Series | Actionable | In a Phase I trial, MT-6402 treatment led to an antitumor immune response and decreased metastatic bone lesions in a CD274 (PD-L1)-positive non-small cell lung cancer patient with osseous metastases (Cancer Res 2022;82(12_Suppl):Abstract nr CT152). | detail... |
| CD274 positive | Advanced Solid Tumor | predicted - resistant | MT-6402 | Preclinical - Cell culture | Actionable | In a preclinical study, MT-6402 treatment demonstrated cytotoxicity in a panel of CD274 (PD-L1)-positive cancer cell lines in culture (Cancer Res 2022;82(12_Suppl):Abstract nr CT152). | detail... |
Filtering
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04795713 | Phase I | MT-6402 | Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1 | Terminated | USA | 0 |
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