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Therapy Name SAR444200
Synonyms
Therapy Description

SAR444200 is a nanobody T-cell engager that binds to both TCR alpha/beta and GPC3, directing cytotoxic T cells to GPC3-expressing tumors, potentially leading to T cell-dependent cellular toxicity (Ann Oncol (2023) 34 (suppl_2): S634).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SAR444200 SAR-444200|SAR 444200 GPC3 Antibody 5 SAR444200 is a nanobody T-cell engager that binds to both TCR alpha/beta and GPC3, directing cytotoxic T cells to GPC3-expressing tumors, potentially leading to T cell-dependent cellular toxicity (Ann Oncol (2023) 34 (suppl_2): S634).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05450562 Phase Ib/II Atezolizumab + SAR444200 SAR444200 Dose Escalation and Expansion Study of SAR444200-based Regimen in Adult Participants With Advanced Solid Tumors Recruiting USA | CAN 3


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