Therapy Detail
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| Therapy Name | SAR444200 |
| Synonyms | |
| Therapy Description |
SAR444200 is a nanobody T-cell engager that binds to both TCR alpha/beta and GPC3, directing cytotoxic T cells to GPC3-expressing tumors, potentially leading to T cell-dependent cellular toxicity (Ann Oncol (2023) 34 (suppl_2): S634). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| SAR444200 | SAR-444200|SAR 444200 | GPC3 Antibody 6 | SAR444200 is a nanobody T-cell engager that binds to both TCR alpha/beta and GPC3, directing cytotoxic T cells to GPC3-expressing tumors, potentially leading to T cell-dependent cellular toxicity (Ann Oncol (2023) 34 (suppl_2): S634). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05450562 | Phase Ib/II | Atezolizumab + SAR444200 SAR444200 | Dose Escalation and Expansion Study of SAR444200-based Regimen in Adult Participants With Advanced Solid Tumors | Active, not recruiting | USA | CAN | 3 |
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