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| Therapy Name | PF-07284890 + PF-07799544 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| PF-07284890 | PF07284890|PF 07284890|ARRY-461|ARRY461|ARRY 461 | BRAF Inhibitor 26 | PF-07284890 inhibits BRAF, potentially leading to inhibition of tumor growth and tumor regression (Cancer Res 2021;81(13_Suppl):Abstract nr 1473). | |
| PF-07799544 | PF 07799544|PF07799544|ARRY-134|ARRY 134|ARRY134 | MEK inhibitor (Pan) 27 | PF-07799544 is a brain-penetrant MEK inhibitor, which reduces downstream signaling and potentially decreases tumor cell proliferation (J Clin Oncol 42, 2024 (suppl 16; abstr 3154), NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05538130 | Phase I | PF-07799544 Encorafenib + PF-07799544 PF-07284890 + PF-07799544 PF-07799544 + PF-07799933 | A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors | Recruiting | USA | ISR | CAN | BRA | AUS | 0 |
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