Therapy Detail
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| Therapy Name | CHM-1101 |
| Synonyms | |
| Therapy Description |
CHM-1101 comprises autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing a CD28 costimulatory domain and CD3zeta domain linked to chlorotoxin (CLTX), which targets MMP2 on tumor cells, and potentially induces cytotoxicity (J Clin Oncol 41, 2023 (suppl 16; abstr TPS2086, NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CHM-1101 | CHM 1101|CHM1101 | CHM-1101 comprises autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing a CD28 costimulatory domain and CD3zeta domain linked to chlorotoxin (CLTX), which targets MMP2 on tumor cells, and potentially induces cytotoxicity (J Clin Oncol 41, 2023 (suppl 16; abstr TPS2086, NCI Drug Dictionary). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05627323 | Phase I | CHM-1101 | CAR T Cells in Patients With MMP2+ Recurrent or Progressive Glioblastoma | Active, not recruiting | USA | 0 |
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