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Therapy Name | CHM-1101 |
Synonyms | |
Therapy Description |
CHM-1101 comprises autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing a CD28 costimulatory domain and CD3zeta domain linked to chlorotoxin (CLTX), which targets MMP2 on tumor cells, and potentially induces cytotoxicity (J Clin Oncol 41, 2023 (suppl 16; abstr TPS2086, NCI Drug Dictionary). |