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Therapy Name AB248
Synonyms
Therapy Description

AB248 is a fusion protein comprised of an anti-CD8 antibody fused to an IL-2 mutein, which preferentially targets CD8+ T-lymphocytes, potentially resulting in increased antitumor immune response (Cancer Res 2022;82(12_Suppl):Abstract nr 3518).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AB248 AB-248|AB 248 AB248 is a fusion protein comprised of an anti-CD8 antibody fused to an IL-2 mutein, which preferentially targets CD8+ T-lymphocytes, potentially resulting in increased antitumor immune response (Cancer Res 2022;82(12_Suppl):Abstract nr 3518).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05653882 Phase I AB248 + Pembrolizumab AB248 A Study Evaluating AB248 Alone or in Combination With Pembrolizumab in Adult Patients With Solid Tumors Recruiting USA 0


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