Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Therapy Name | SAR445877 |
Synonyms | |
Therapy Description |
SAR445877 is an antibody cytokine fusion molecule comprising an anti-PD-1 (PDCD1) antibody linked to a mutated fusion of human IL15 and human IL15 receptor-alpha sushi domain, which potentially inhibits tumor growth (Cancer Res (2023) 83 (7_Supplement): 2972). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
SAR445877 | SAR 445877|SAR-445877|KD 050|KD-050|KD050|mut-1N-IL-15/38B2 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 | SAR445877 is an antibody cytokine fusion molecule comprising an anti-PD-1 (PDCD1) antibody linked to a mutated fusion of human IL15 and human IL15 receptor-alpha sushi domain, which potentially inhibits tumor growth (Cancer Res (2023) 83 (7_Supplement): 2972). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT05584670 | Phase Ib/II | SAR445877 | A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors | Recruiting | USA | NLD | ISR | ESP | 0 |