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Therapy Name	SHR-A1921
Synonyms
Therapy Description	SHR-A1921 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting TROP2 conjugated to a DNA topoisomerase I inhibitor, which potentially induces tumor cell killing and and inhibits growth of tumors expressing TROP2 (Cancer Res (2023) 83 (8_Supplement): LB030, Cancer Res (2023) 83 (8_Supplement): CT181).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
SHR-A1921		SHR A1921\|SHRA1921\|SHRA 1921\|SHR-1921	TROP2 Antibody 18	SHR-A1921 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting TROP2 conjugated to a DNA topoisomerase I inhibitor, which potentially induces tumor cell killing and and inhibits growth of tumors expressing TROP2 (Cancer Res (2023) 83 (8_Supplement): LB030, Cancer Res (2023) 83 (8_Supplement): CT181).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT05594875	Phase I	SHR-A1921	A Trial of SHR-A1921 for Injection in Subjects With Advanced Solid Tumors	Completed	AUS	0

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