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Therapy Name STK-009 + SYNCAR-001
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
STK-009 STK009|STK009 STK-009 is an IL-2 mutein that stimulates a modified form of IL-2 receptor beta (IL-2R beta) while not stimulating wild-type IL-2R beta, potentially leading to enhanced antitumor response in combination with CAR T cells expressing the modified IL-2R beta (Cancer Res (2022) 82 (12_Supplement): 2824).
SYNCAR-001 SYNCAR 001|SYNCAR001 CD19 Immune Cell Therapy 62 SYNCAR-001 are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD19 as well as a mutated IL-2 receptor beta, which have potential antitumor activity (Cancer Res (2021) 81 (13_Supplement): 1512).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05665062 Phase I Cyclophosphamide + Fludarabine STK-009 + SYNCAR-001 Autologous CD19 CAR-T Cell Therapy (SYNCAR-001) + Orthogonal IL-2 (STK-009) in Subjects With CD19+ Hematologic Malignancies Recruiting USA 0


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