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Therapy Detail
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| Therapy Name | STK-009 + SYNCAR-001 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| STK-009 | STK009|STK009 | STK-009 is an IL-2 mutein that stimulates a modified form of IL-2 receptor beta (IL-2R beta) while not stimulating wild-type IL-2R beta, potentially leading to enhanced antitumor response in combination with CAR T cells expressing the modified IL-2R beta (Cancer Res (2022) 82 (12_Supplement): 2824). | ||
| SYNCAR-001 | SYNCAR 001|SYNCAR001 | CD19 Immune Cell Therapy 65 | SYNCAR-001 are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD19 as well as a mutated IL-2 receptor beta, which have potential antitumor activity (Cancer Res (2021) 81 (13_Supplement): 1512). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05665062 | Phase I | Cyclophosphamide + Fludarabine STK-009 + SYNCAR-001 | Autologous CD19 CAR-T Cell Therapy (SYNCAR-001) + Orthogonal IL-2 (STK-009) in Subjects With CD19+ Hematologic Malignancies | Active, not recruiting | USA | 0 |
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